From Tucson, take I-19 south toward Green Valley and Nogales.
Exit I-19 at Duval Mine Road (exit 69).
Turn west (right) on Duval Mine Road. Follow the signs to the Titan Missile National Historic Landmark. The entrance to the museum is on the north (right) side of the road approximately 1/10th mile past the intersection of La Canada and Duval Mine Road.